COVID-19's natural course among ambulatory monitored outpatients.
作者： Barbora Weinbergerova , Martina Lengerova , Martina Doubkova , Kristian Brat , Petr Husa
DOI: 10.1038/S41598-021-89545-1
关键词:
摘要: Research objective was to detail COVID-19's natural trajectory in relation the Czech population's viral load. Our prospective detailed daily questionnaire-based telemonitoring study evaluated impact among 105 outpatients. In accordance with government quarantine requirements, outpatients were divided into a cohort two negative tests at end of disease (40 patients) and new algorithm (65 following 14-day quarantine. Median follow-up differed significantly between 2 groups (23 days vs. 16 days). Only 6% patients asymptomatic during entire period. Another 13% diagnosed asymptomatic, as suspected contacts, yet later developed symptoms, while remaining 81% symptomatic on average 6 days symptom onset. Telemonitoring enabled precise status chronicling. The most frequently reported complaints fevers, respiratory issues, anosmia. Six eventually hospitalized for complications detected early after routine telemonitoring. During extended (median 181 days), anosmia persisted 26% patients. 79% no symptoms day 11 compared just 56% test upon first testing (median-19 days). highest load occurred within 0-2 days initial Both PCR consecutive sample realizations indicated high interindividual variability surprisingly fluctuating pattern 43% No definitive COVID-19 or set excepting (59%) and/or ageusia (47%) identified. preexisting medical conditions specifically foreshadowed given patient. Without negativity requirement cessation, could exhibit fewer symptoms. therefore highlights urgent need ambulatory patient telemedicine monitoring, complication detection, intensive mass education connecting demeanor subsequent swift diagnostics, and, notably, reevaluate modify regulations better control SARS-CoV-2 proliferation.
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