Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone
作者： Melissa D. Howard , Andrei Ponta , Allison Eckman , Michael Jay , Younsoo Bae
DOI: 10.1007/S11095-011-0470-1
关键词:
摘要: Purpose To develop polymer micelles for the tunable release of Dexamethasone (DEX) in tumors. Methods DEX was conjugated to poly (ethylene glycol)-poly (aspartate) block copolymers using hydrazone, ester, or hydrazone-ester dual linkers. Ketonic acids containing 3, 4, and 5 methylene groups were used as spacers to separate the dual linkers. Polymer micelles from the DEX-conjugated polymers were tested for drug release at different pH values and carboxylesterase activity levels. Results DLS measurements and 1 …
springer.com
sci-hub.se 参考文章(56)
D. Putnam, J. Kopeček, Polymer conjugates with anticancer activity Advances in Polymer Science. ,vol. 122, pp. 55- 123 ,(1995) , 10.1007/3540587888_14
至彦 藤田, What's going on ゲノム Drug interactions in cancer therapy. Scripture CD, Figg WD. Nat Rev Cancer. 2006; 6: 546-58. PMID: 16794637. 癌治療における薬物相互作用のおもな実例と作用機序を示した総説 Mebio oncology. ,vol. 3, pp. 88- 90 ,(2006)
Valentino J. Stella, Sumie Yoshioka, Stability of Drugs and Dosage Forms ,(2000)
Denis Franchimont, Jérôme Galon, Massimo Gadina, Roberta Visconti, Y.-J. Zhou, Martin Aringer, David M. Frucht, George P. Chrousos, John J. O’Shea, Inhibition of Th1 Immune Response by Glucocorticoids: Dexamethasone Selectively Inhibits IL-12-Induced Stat4 Phosphorylation in T Lymphocytes The Journal of Immunology. ,vol. 164, pp. 1768- 1774 ,(2000) , 10.4049/JIMMUNOL.164.4.1768
N. Auphan, J. A. DiDonato, C. Rosette, A. Helmberg, M. Karin, Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis Science. ,vol. 270, pp. 286- 290 ,(1995) , 10.1126/SCIENCE.270.5234.286
Dong Wang, Scott C Miller, Xin-Ming Liu, Brian Anderson, X Sherry Wang, Steven R Goldring, Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis Arthritis Research & Therapy. ,vol. 9, pp. 1- 9 ,(2007) , 10.1186/AR2106
Joshua H. Atkins, Leland J. Gershell, Selective anticancer drugs Nature Reviews Cancer. ,vol. 2, pp. 645- 646 ,(2002) , 10.1038/NRC900
Yoshinobu Takakura, Mitsuru Hashida, Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution. Pharmaceutical Research. ,vol. 13, pp. 820- 831 ,(1996) , 10.1023/A:1016084508097
Yasuhiro Matsumura, Hiroshi Maeda, A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Research. ,vol. 46, pp. 6387- 6392 ,(1986)
M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono, Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 3460- 3465 ,(2007) , 10.1073/PNAS.0611660104