Prions and their lethal journey to the brain.
作者： Neil A. Mabbott , G. Gordon MacPherson
DOI: 10.1038/NRMICRO1346
关键词:
摘要: Prion diseases are neurodegenerative conditions that cause extensive damage to nerve cells within the brain and can be fatal. Some prion disease agents accumulate first in lymphoid tissues, as they make their journey from site of infection, such gut, brain. Studies mouse models have shown this accumulation is obligatory for efficient delivery prions Indeed, if tissues blocked, susceptibility reduced. Therefore, identification molecules involved might identify targets therapeutic intervention. This review describes current understanding mechanisms
nature.com
sci-hub.se 参考文章(142)
N. Imazeki, A. Senoo, Y. Fuse, Is the follicular dendritic cell a primarily stationary cell Immunology. ,vol. 76, pp. 508- 510 ,(1992)
T K van den Berg, C D Dijkstra, K Yoshida, Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping. Immunology. ,vol. 80, pp. 34- 39 ,(1993)
P. Brown, The risk of blood-borne Creutzfeldt--Jakob disease. Developments in biologicals. ,vol. 102, pp. 53- 59 ,(2000)
T. K. Van den Berg, K. Yoshida, C. D. Dijkstra, Mechanism of Immune Complex Trapping by Follicular Dendritic Cells An Antigen Depository of the Immune System: Follicular Dendritic Cells. ,vol. 201, pp. 49- 67 ,(1995) , 10.1007/978-3-642-79603-6_3
Louis Court, Transmissible Subacute Spongiform Encephalopathies : Prion Diseases Elsevier Science Ltd. ,(1996)
Neil A. Mabbott, Moira E. Bruce, Marina Botto, Mark J. Walport, Mark B. Pepys, Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie Nature Medicine. ,vol. 7, pp. 485- 487 ,(2001) , 10.1038/86562
Neil A. Mabbott, Fabienne Mackay, Fiona Minns, Moira E. Bruce, Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie Nature Medicine. ,vol. 6, pp. 719- 720 ,(2000) , 10.1038/77401
A K Szakal, J G Tew, L D Shultz, G F Burton, Z F Kapasi, Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells. Journal of Immunology. ,vol. 150, pp. 2648- 2658 ,(1993)
Frank L. Heppner, Andreas D. Christ, Michael A. Klein, Marco Prinz, Michael Fried, Jean-Pierre Kraehenbuhl, Adriano Aguzzi, Transepithelial prion transport by M cells Nature Medicine. ,vol. 7, pp. 976- 977 ,(2001) , 10.1038/NM0901-976
Alexander Peden, James Ironside, Mark Head, Diane Ritchie, Jeanne Bell, Preclinical variant CJD after blood transfusion in a PRNP codon 129 heterozygous patient Joint Funders' Transmissible Spongiform Encephalopathies Workshop. ,(2004)