Importance of individuality in oxidative stress and aging 1,2 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.
作者： Earl R Stadtman
DOI: 10.1016/S0891-5849(02)00904-8
关键词:
摘要: Tight linkage between aging and oxidative stress is indicated by the observations that reactive oxygen species generated under various conditions of are able to oxidize nucleic acids, proteins, lipids associated with accumulation oxidized forms cellular constituents, also fact there an inverse relationship maximum life span organisms age-related damage. Nevertheless, validity hypothesis questioned (i) failure establish a causal damage (ii) lack consistent correlation aging. The present discussion focused on complexity process suggests discrepancies studies in this area likely due not single experimental results partly explained individual variations. Even so, overwhelming support for dominant role some individuals.
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