Adult human mesenchymal stromal cells and the treatment of graft versus host disease

摘要: Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor human leucocyte antigen (HLA) mismatch normally treated corticosteroid other immunosuppressive therapy. When it refractory to steroid therapy, mortality approaches 80%. Mesenchymal stromal cells are rare found in bone marrow tissues. They can be expanded culture possess complex diverse immunomodulatory activity. Moreover, mesenchymal carry low levels class 1 no 2 HLA antigens, making them immunoprivileged able used without matching. Their use steroid-refractory graft was first described 2004. Subsequently, they have been number Phase I II trials acute chronic success. We discuss their mode action, the results, production, potential dangers view future application.