Platelet adhesiveness and aggregation in relation to diabetic retinopathy

摘要: Platelet adhesiveness, ADP-activated platelet aggregation and the activity of ADP-splitting enzymes in blood plasma have been studied 22 diabetics with severe retinopathy, long-duration minimal or no retinopathy 28 control subjects. The rate under influence 5, 3, 2 1 μM ADP, maximum attained disaggregation these aggregates were measured. platelets from actively deteriorating retinopaths found to be more sensitive effect low concentrations ADP; a significant increase extent decrease formed experimental conditions,in vitro observed. If this should occurin vivo, then capillary occlusion might ensue. This increased sensitivity ADP inability disaggregate, was not due any differences enzyme systems blood. Significant parameters observed when large diabetic groups compared Contrary some reports, an adhesiveness apparent either group.