Chlortetracycline-Functionalized Silver Nanoparticles as a Colorimetric Probe for Aminoglycosides: Ultrasensitive Determination of Kanamycin and Streptomycin

摘要: Aminoglycosides (AMGs) have been extensively used to treat infectious diseases caused by Gram-negative bacteria in livestock and humans. A selective sensitive colorimetric probe for the determination of streptomycin kanamycin was proposed based on chlortetracycline-coated silver nanoparticles (AgNPs-CTC) as sensing element. Almost all tested aminoglycoside antibiotics can rapidly induce aggregation AgNPs, along with a color change from yellow orange/red. The detection antibiotics, including tobramycin, streptomycin, amikacin, gentamicin, neomycin, kanamycin, other types be achieved ultraviolet (UV) spectroscopy. This developed assay has ability detect various AMGs using in-depth surface plasmon resonance (SPR) studies. With this at picomolar level (pM) UV-visible spectrophotometer. Under aqueous conditions, linear range sensor 1000-1,1000 120-480 pM, respectively. corresponding limit 2000 pM 120 Thus, validated dual ratiometric method find analytical applications ultrasensitive rapid AMG water samples.