Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.

摘要: Objective: Published data concerning associations between IRS1 variants and type 2 diabetes related traits have been inconsistent. We examined the relationship common in IRS1, diabetes, including insulin resistance, hyperglycemia DNA damage Boston Puerto Rican Health Study. Methods: genotyped six an adult population (n=1132) tested for association with risk of traits. Results: SNPs rs934167 rs1801123 showed significant fasting glucose concentrations (p = 0.005 p 0.016, respectively) plasma levels 0.005). Carriers minor allele had significantly higher HOMA-IR lower QUICKI 0.001 0.001, respectively), a 40% 58% greater likelihood being hyperglycaemic or hyperinsulinemic (OR 1.40 1.58; 0.013 0.002, respectively). However, they exhibited only marginally trend towards having (OR=1.27, 0.077). Furthermore, carriers haplotype C-T alleles consistent patterns after correction multiple testing. In addition, G972R (rs1801278) was associated urinary 8-OHdG 0.020) CRP 0.035). Conclusions: Our results support Ricans. Moreover, we report novel finding that variant may contribute to oxidative inflammation.