Caenorhabditis elegans Models of Human Neurodegenerative Diseases

作者: Richard Nass , Lihsia Chen

DOI: 10.1007/978-1-59745-285-4_12

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摘要: Within the past decade it has become remarkably clear that molecular components involved in basic cellular function and dysfunction are highly conserved across phyla from single cell organisms to humans. The high sequence similarities within eukaryotes advent of technologies now allow us utilize genetic models such as nematode C. elegans begin elucidate complex mechanisms human neurodegenerative diseases. In this chapter we will briefly summarize recent advances using model a number diseases including Parkinson’s disease, Alzheimer’s Huntington’s hereditary spastic paraplegia, describe how relatively simple animal is being utilized identify putative endogenous exogenous molecules may contribute disease. We also genetically tractable organism amenable throughput novel drug targets potential therapeutic leads combat these devastating neurological disorders.

参考文章(145)
Ian D. Hope, C. elegans : a practical approach Oxford University Press (OUP). ,(1999)
G. U. Hoöglinger, W. H. Oertel, E. C. Hirsch, The rotenone model of parkinsonism--the five years inspection. Journal of Neural Transmission-supplement. pp. 269- 272 ,(2006) , 10.1007/978-3-211-45295-0_41
Yelena Glinka, M. Gassen, M. B. H. Youdim, Mechanism of 6-hydroxydopamine neurotoxicity Journal of Neural Transmission-supplement. ,vol. 50, pp. 55- 66 ,(1997) , 10.1007/978-3-7091-6842-4_7
Soon-Tae Lee, Manho Kim, None, Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease. Mechanisms of Ageing and Development. ,vol. 127, pp. 432- 435 ,(2006) , 10.1016/J.MAD.2006.01.022
Frank M. LaFerla, Steven F. Hinton, Michael C. Sugarman, Transgenic Models of Alzheimer’s Disease Humana Press, Totowa, NJ. pp. 51- 72 ,(2001) , 10.1007/978-1-59259-006-3_2
JianPing Lu, Faiza Rashid, Paula C. Byrne, The hereditary spastic paraplegia protein spartin localises to mitochondria Journal of Neurochemistry. ,vol. 98, pp. 1908- 1919 ,(2006) , 10.1111/J.1471-4159.2006.04008.X
Lisa Timmons, Andrew Fire, Specific interference by ingested dsRNA Nature. ,vol. 395, pp. 854- 854 ,(1998) , 10.1038/27579
Jamilé Hazan, Nùria Fonknechten, Delphine Mavel, Caroline Paternotte, Delphine Samson, François Artiguenave, Claire-Sophie Davoine, Corinne Cruaud, Alexandra Dürr, Patrick Wincker, Philippe Brottier, Laurence Cattolico, Valérie Barbe, Jean-Marc Burgunder, Jean-François Prud'homme, Alexis Brice, Bertrand Fontaine, Roland Heilig, Jean Weissenbach, Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia Nature Genetics. ,vol. 23, pp. 296- 303 ,(1999) , 10.1038/15472
E. A. A. Nollen, S. M. Garcia, G. van Haaften, S. Kim, A. Chavez, R. I. Morimoto, R. H. A. Plasterk, Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 6403- 6408 ,(2004) , 10.1073/PNAS.0307697101
Mike Hutton, Corinne L. Lendon, Patrizia Rizzu, Matt Baker, Susanne Froelich, Henry Houlden, Stuart Pickering-Brown, Sumi Chakraverty, Adrian Isaacs, Andrew Grover, Jennifer Hackett, Jennifer Adamson, Sarah Lincoln, Dennis Dickson, Peter Davies, Ronald C. Petersen, Martijn Stevens, Esther de Graaff, Erwin Wauters, Jeltje van Baren, Marcel Hillebrand, Marijke Joosse, Jennifer M. Kwon, Petra Nowotny, Lien Kuei Che, Joanne Norton, John C. Morris, Lee A. Reed, John Trojanowski, Hans Basun, Lars Lannfelt, Michael Neystat, Stanley Fahn, Francis Dark, Tony Tannenberg, Peter R. Dodd, Nick Hayward, John B. J. Kwok, Peter R. Schofield, Athena Andreadis, Julie Snowden, David Craufurd, David Neary, Frank Owen, Ben A. Oostra, John Hardy, Alison Goate, John van Swieten, David Mann, Timothy Lynch, Peter Heutink, Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 Nature. ,vol. 393, pp. 702- 705 ,(1998) , 10.1038/31508