作者: Richard Nass , Lihsia Chen
DOI: 10.1007/978-1-59745-285-4_12
关键词:
摘要: Within the past decade it has become remarkably clear that molecular components involved in basic cellular function and dysfunction are highly conserved across phyla from single cell organisms to humans. The high sequence similarities within eukaryotes advent of technologies now allow us utilize genetic models such as nematode C. elegans begin elucidate complex mechanisms human neurodegenerative diseases. In this chapter we will briefly summarize recent advances using model a number diseases including Parkinson’s disease, Alzheimer’s Huntington’s hereditary spastic paraplegia, describe how relatively simple animal is being utilized identify putative endogenous exogenous molecules may contribute disease. We also genetically tractable organism amenable throughput novel drug targets potential therapeutic leads combat these devastating neurological disorders.