Regulation of inflammation and redox signaling by dietary polyphenols

摘要: Reactive oxygen species (ROS) play a key role in enhancing the inflammation through activation of NF-kappaB and AP-1 transcription factors, nuclear histone acetylation deacetylation various inflammatory diseases. Such undesired effects oxidative stress have been found to be controlled by antioxidant and/or anti-inflammatory dietary polyphenols such as curcumin (diferuloylmethane, principal component turmeric) resveratrol (a flavonoid red wine). The phenolic compounds fruits, vegetables, tea wine are mostly derivatives, isomers flavones, isoflavones, flavonols, catechins, tocopherols, acids. Polyphenols modulate important cellular signaling processes growth, differentiation host other features. In addition, they activation, chromatin structure, glutathione biosynthesis, redox factor (Nrf2) scavenge effect ROS directly or via peroxidase activity consequence regulate genes macrophages lung epithelial cells. However, recent data suggest that can work modifiers signal transduction pathways elicit their beneficial effects. however, reported more pronounced vitro using high concentrations which not physiological vivo. This commentary discusses on control particularly during stress, metabolism bioavailability.