Predictors of Rapid Progression to AIDS in HIV-1 Seroconverters

摘要: OBJECTIVE: To determine whether at the time of HIV-1 seroconversion rapid progressors to AIDS and a low CD4+ count can be distinguished by clinical presentation primary infection serological immunological characteristics. DESIGN: Prospective cohort study on in homosexual men. SETTING: The Municipal Health Service, Amsterdam, Netherlands. SUBJECTS: One hundred eight men who seroconverted for during follow-up. MAIN OUTCOME MEASURES: Progression progression lymphocyte < 200 x 10(6)/l. RESULTS: Symptomatic HIV with fever skin rash, absence anti-HIV core transient p24 antigenemia were independent predictors seroconversion. A immediately after calendar year CONCLUSIONS: Even earliest stage small group individuals high risk recognized infection, presence antigenaemia response protein.