The antinociceptive effect of zolpidem and zopiclone in mice.

摘要: Zolpidem and zopiclone are two of a newer hypno-sedative class drugs, the "Z compounds". Their use for treatment short-term insomnia has been expanding constantly during last decades. The compounds" considered to cause less significant rebound or tolerance than conventional hypnotic benzodiazepines. possible antinociceptive effect interaction with opioid system not studied yet. Our results demonstrate difference between properties zolpidem when injected s.c. in hotplate analgesic assay mice. Zopiclone induced weak, dose-dependent effect, antagonized only by alpha2-adrenergic receptor antagonist yohimbine. biphasic primarily non-selective naloxone weak both evident at very high doses (far beyond those used clinically induce sleep), implies no clinical management pain. However, should be further investigated (in behavioral models, which do overlap acute-pain antinociception model we used), side effects special populations (i.e. elderly) drug-drug interactions, order minimize hazards maximize beneficial its sleep.