Chapter 19. Diabetes Mellitus

摘要: Publisher Summary This chapter elaborates key developments in the field of diabetes mellitus. The concept that mellitus is a disease diverse nature has been affirmed by further understanding its etiology and associated hormonal metabolic defects. process insulin secretion involves movement secretory granules, which conversion proinsulin to occurs, periphery cell through microtubular–microfilamentous system. A large variety compounds serve as secretagogues for these include sugars, amino acids, hormones, cations, modifiers, hypoglycemic. regulation this complex multifactorial it plays an immensely important role maintaining normoglycemia animals. In obese-hyperglycemic mutant mouse, insulin-resistance appears correlate directly with irreversible deficiency receptor activity on adipocyte hepatocyte plasma membranes. diabetogenic effects growth hormone have postulated be mediated insulin-antagonistic peptide, somantin, released at membranes growth-hormone sensitive tissues. Diabetogenic peptide isolated from urine pituitaries also reported possess effects.