Alteplase (rtPA) treatment of intraventricular hematoma (IVH): safety of an efficient methodological approach for rapid clot removal.

摘要: Intraventricular hemorrhage (IVH) subsequent to intracerebral (ICH) or subarachnoid (SAH) is associated with high mortality and morbidity. The use of fibrinolytic agents treat this condition has previously been reported in small clinical trials limited numbers patients. Variability regarding inclusion criteria, method administration outcome have made it difficult draw firm conclusions the efficacy antifibrinolytic therapy. Nine patients CT-diagnosed IVH were treated Alteplase intrathecally for 3 5 days according CT-verified clearance IVH. After treatment period, a repeat CT scan was performed evaluate effect.