Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.

摘要: CA3-CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these consistent with their proposed network functions remains unclear. Here, we examine spike timing-dependent (STDP) at synapses. Low-frequency pairing postsynaptic potentials (EPSPs) action (APs) induces long-term potentiation (LTP), independent temporal order. The STDP curve is symmetric broad (half-width ∼150 ms). Consistent induction properties, AP-EPSP sequences lead supralinear summation spine [Ca(2+)] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites CA3 pyramidal neurons, EPSPs summate dendritic ADPs. In autoassociative models, recall more robust than asymmetric rules. Thus, specialized rule allows reliable information hippocampal network.