Toluene Tolerance Systems in Pseudomonas

摘要: Organic solvents such as monoaromatic hydrocarbons are highly toxic for living cells; however, most Pseudomonas putida strains able to grow in the presence of low concentrations these compounds. The cellular response toward organic culture media is multifactorial. An early and quick a decreased fluidity cell membrane via cis–trans isomerization unsaturated fatty acids. This followed by transcriptional reprogramming, leading induction stress-related functions metabolic pathways increase energy production. used microbe extrude compounds outer medium efflux pumps RND (resistance, nodulation, division) family—one effective mechanisms solvent tolerance. All processes concur majority P. studied so far. There number that have been described tolerant; strains, action one pump (named TtgGHI strain DOT-T1E) required full tolerance second phase solvent.