Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction

摘要: Objectives The aim of this research was to assess the incidence, clinical predictors, and outcome contrast-induced nephropathy (CIN) after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Background Contrast-induced is associated with significant morbidity mortality PCI. Patients undergoing PCI may be at higher risk CIN because hemodynamic instability unfeasibility adequate prophylaxis. Methods In 208 consecutive AMI patients PCI, we measured serum creatinine concentration (Cr) baseline each day following three days. defined as a rise in Cr g0.5 mg/dl. Results Overall, occurred 40 (19%) patients. Of 160 clearance ≥60 ml/min, only 21 (13%) developed CIN, whereas it 19 (40%) those l60 ml/min (p l 0.0001). multivariate analysis, age g75 years (odds ratio [OR] 5.28, 95% confidence interval [CI] 1.98 14.05; p = 0.0009), anterior (OR 2.17, CI 0.88 5.34; 0.09), time-to-reperfusion g6 h 2.51, 1.01 6.16; 0.04), contrast agent volume g300 ml 2.80, 1.17 6.68; 0.02) use intraaortic balloon 15.51, 4.65 51.64; 0.0001) were independent correlates CIN. developing had longer hospital stay (13 ± 7 days vs. 8 3 days; 0.001), more complicated course, significantly rate (31% 0.6%; 0.001). Conclusions frequently complicates even normal renal function. It in-hospital complication mortality. Thus, preventive strategies are needed, particularly high-risk