Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches.

摘要: The biopharmaceutical industry is at a turning point moving toward more customized and patient-oriented medicine (precision medicine). Straightforward routines such as the antibody platform process are extended to production processes for new portfolio of molecules. As consequence, individual tailored productions require generic approaches fast dedicated purification development. In this article, different effective strategies in development reviewed that can analogously be used generation antibodies. Conventional based on heuristics high-throughput discussed compared modern technologies multivariate calibration mechanistic modeling tools. Such constitute good foundation products processes, but their full potential becomes obvious correlated combination. Thus, combinatorial presented, which might become future directions industry.