Targeting cognitive deficits in schizophrenia: a review of the development of a new class of medicines from the perspective of community mental health researchers

摘要: Introduction: Schizophrenia is a chronic disorder associated with positive and negative symptoms wide-ranging deficits in neurocognitive function. Neurocognitive are considered to be the core pathophysiological of illness. also closely functional outcome. At present, cognitive remain one most important unmet therapeutic needs schizophrenia. Areas covered: Neuroscientific discoveries over past decades have enriched our understanding neurobiological mechanism underlying This research has identified new molecular mechanisms processes as promising pharmacological targets. However, spite extensive efforts develop class cognitive-enhancing medicines for treatment schizophrenia 5 years, no novel agents received regulatory approvals required by Food Drug Administration. The efficacy safety outcomes f...