Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith

摘要: A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in therapeutically effective amount and preferably further one or more pharmaceutically active drugs such as an anti-inflammatory glucocorticosteroid, sympathomimetic amine decongestant, anti-histamine, local anesthetic, menthol analog, mixtures thereof. The may be represented by the general formula 1-[R1-phenyl]-4-[R2-phenyl]-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl; R2 -nitro, -trifluoromethyl. Therapeutic compositions of invention elicit long-lasting cooling soothing, particularly when formulated for delivery to suppress sensations itch pain, inflamed skin, mucous membranes anogenital areas, enteric mucosa.