Dual function of sialic acid in gastrointestinal SARS-CoV-2 infection.
作者： Ayse Basak Engin , Evren Doruk Engin , Atilla Engin
DOI: 10.1016/J.ETAP.2020.103436
关键词:
摘要: Recent analysis concerning the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- angiotensin converting enzyme (ACE) receptor interaction in enterocytes, definition of gut-lung axis, as well molecular basis sialic acid-related dual recognition concept gastrointestinal SARS-CoV-2 infection, have brought a new perspective to potential therapeutic targets. In this review evolving research and clinical data on infection are discussed context viral fusion entry mechanisms, focusing different triggers used by coronaviruses. Furthermore, it is emphasized that spike protein prevented from binding gangliosides, which composed glycosphingolipid with one or more acids, presence chloroquine hydroxychloroquine. efficiency these repositioned drugs debated.
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