Immunological approaches for the control of fasciolosis

摘要: The immunological relationship between liver flukes and their mammalian hosts is being unravelled by in vivo vitro studies. Vaccine studies cattle sheep with purified antigens (fatty acid binding protein, FABP; glutathione S-transferase, GST; cathepsin L, CatL; hemoglobin) have shown that high reductions worm burdens (31-72%) egg production (69-98%) can be achieved, raising the realistic possibility control of Fasciola infection a commercially achievable goal. Combination vaccines may also feasible since cocktail CatL hemoglobin elicits significant 72% protection cattle. Analysis immune responses to during ruminants suggests chronic correlates type 2 helper T cell response, implying 1 are down-regulated fasciolosis. Recent results studying resistance Indonesian Thin Tail (ITT) F. gigantica this breed exhibits innate (or rapidly acquired) acquires higher level after primary challenge. Initial suggest ITT determined major gene. Merino acquire gigantica. In contrast, do not exhibit hepatica. These there fundamental differences these two species biology interaction system. on mechanisms killing juvenile fluke larvae hepatica susceptible antibody-dependent activated rat macrophages which mediated nitric oxide. Future effector expressed resistant will lead new knowledge allow design more effective for