On the role of classical and novel forms of vitamin D in melanoma progression and management

摘要: Melanoma represents a significant clinical problem affecting large segment of the population with relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is an important etiological factor in malignant transformation melanocytes melanoma development. UVB, while being full carcinogen melanomagenesis, also necessary for cutaneous production vitamin D3 (D3). Calcitriol (1,25(OH)2D3) novel CYP11A1-derived hydroxyderivatives show anti-melanoma activities protective properties against damage induced by UVB. The former include inhibitory effects on proliferation, plating efficiency anchorage-independent growth cultured human rodent melanomas vitro, as well vivo inhibition tumor 20(OH)D3 after injection cells into immunodeficient mice. literature indicates that low levels 25(OH)D3 are associated more advanced reduced patient survivals, single nucleotide polymorphisms D receptor or binding protein gene affect development progression melanoma, disease outcome. An inverse correlation VDR CYP27B1 expression has been found, undetectable these proteins poor outcomes. Unexpectedly, increased CYP24A1 was better prognosis. In addition, decreased retinoic acid orphan receptors α γ, which can bind hydroxyderivatives, showed positive association shorter disease-free overall survival. Thus, inadequate biologically active forms disturbances target receptors, activating inactivating enzymes, melanomagenesis progression. We therefore propose inclusion management should be beneficial patients, at least adjuvant approach. presence multiple skin activity experimental models may act alternative will future consideration when planning to use therapy.