A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI).

摘要: To measure the stiffness of aorta, femoral artery and tibial noninvasively, cardio-ankle vascular index (CAVI) which is independent blood pressure was developed. The formula for measuring this is; CAVI=a{(2rho/DeltaP) x ln(Ps/Pd)PWV(2)} + b where, Ps Pd are systolic diastolic pressures respectively, PWV pulse wave velocity between heart ankle, DeltaP - Pd, rho density, a constants. This equation derived from Bramwell-Hill's equation(1)), parameter(2)). elucidate clinical utility CAVI, reproducibility dependence on were studied using VaSera (Fukuda Denshi Co., Ltd.). Furthermore, CAVI in hemodialysis patients with or without atherosclerotic diseases measured. average coefficient variation five measurements among 22 persons 3.8%. In (n = 482), correlated weakly (R 0.175, 0.006), while brachial-ankle strongly 0.463, 0.335). signs (NA) 8.1 +/- 0.3 (mean SD). That receiving percutaneous transluminal coronary angioplasty 8.8 (p < 0.05 vs. NA). ischemic change their electrocardiogram (ECG) 8.5 diabetes mellitus 0.002 all three complications 8.9 0.35 0.001 These results suggested that could reflect arteriosclerosis quantitatively.