Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces

摘要: Contact inhibition of locomotion (CIL) is the process through which cells move away from each other after cell-cell contact, and it contributes to malignant invasion developmental migration. Various cell types exhibit CIL, whereas others remain in contact collision may form stable junctions. To investigate what determines this differential behavior, we study neural crest cells, a migratory stem population whose invasiveness has been likened cancer metastasis. By comparing pre-migratory show that switch E- N-cadherin during EMT essential for acquisition CIL behavior. Loss E-cadherin leads repolarization protrusions, via p120 Rac1, resulting redistribution forces intercellular tension cell-matrix adhesions, break down cadherin junction. These data provide insight into balance physical vivo.