Acute dermatomyositis-polymyositis and malignancy

摘要: Abstract A partial review of selected published case reports AD-P associated with malignancy has been enhanced by the presentation pertinent data on 15 unreported examples association. It is noteworthy that first in current literature a was described 1916. The brief clinical report patient proximal muscle weakness and skin lesions, obvious association (adenocarcinoma stomach), describes an example repeated many times different types tumors but essentially no variations findings. In 1959 Williams identified 590 cases AD overall tumor rate 15%, 31 recently Barnes 258 malignancy. 33 original designation, dermatomyositis or AD, now expanded to include polymyositis systemic involvement, which syndrome at state art indistinguishable clinically pathologically from except for lack lesions. may be some future time one more immunologic features differentiate entity further subdivide each these entities similar syndromes However, problem management either similar. 1 number patients neuropathy have reported. These associations mentioned briefly, insufficient are available determine whether should considered as variant only casually related conditions certain common. Most had lesions; minority lacked this feature. unless followed carefully, it possible transient evanescent erythema insignificant lesions present not recorded record. AD-P, there laboratory findings unique contrast carcinoma unassociated nor those without malignancy, fatal determination, usually attributed florid type dermatomyositis, better rapidly progressive relentless weakness, failure respiratory pharyngeal musculature. Approximately 15% typical Sometimes precedes symptoms collagen-vascular disease years. other patients, reverse true period time. few two chronologically unrelated appeared. favor than casual relationship, e.g., recent study Barnes. Another survey casts doubt relationship. 97 We still epidemiologic information based upon statistically reliable combined condition, comprehensive country respect decades life, sex, site tumor. 34 cause most malignancies unknown. easy speculate positively versus negatively diseases might their initiating pathogenesis same time, predominating weeks, months, even I tend concomitant disproportionate development symptoms. At moment virus participating seems intriguing, firm proof lacking. Females predominate because larger genital breast tumors, quite counterbalanced lung gastrointestinal tract, common male. newly reported presented review, males exceeded females ratio 2:1, probably majority came army VA hospitals. appearance adult comes after age 40 yr. noninvasive prepuberty years One girl 10 yr chromophobe adenoma. when second patient, boy hyperplasia adrenals, appeared Also, three leukemia children. Note also made 17-yr-old male reticuloendotheliosis. This borderline between childhood adulthood. previously probable Wilms removed 17 developed 7 later. observations negate statement disease. treatment malignancy; holds Furthermore, expect use corticosteroids immunosuppressive drugs, useful beneficial effect. There too observed make any statements category. my series, E.A., received large doses course methotrexate, inevitably regressive. Several frequently early were seen series new observed. concerns incidence arthralgias, sometimes called atypical RA, sclerodermatous changes subcutaneous calcinosis, Raynaud phenomenon. assumed low unreported.