Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung

摘要: Targeted aerosol delivery to specific regions of the lung may improve therapeutic efficiency and minimise unwanted side effects. could potentially be achieved with porous microparticles loaded superparamagnetic iron oxide nanoparticles (SPIONs)-in combination a target-directed magnetic gradient field. The aim this study was formulate evaluate aerodynamic properties SPIONs-loaded Trojan after from dry powder inhaler. Microparticles made SPIONs, PEG hydroxypropyl-β-cyclodextrin (HPβCD) were formulated by spray drying characterised various physicochemical methods. Aerodynamic evaluated using next generation cascade impactor (NGI), or without magnet positioned at stage 2. Mixing appropriate proportions HPβCD allowed microparticle formulated. These particles had median geometric diameter 2.8±0.3μm shown sensitive field induced having maximum energy product 413.8kJ/m(3). However, these particles, mass (MMAD) 10.2±2.0μm, considered not inhalable. poor resulted aggregation particles. addition (NH4)2CO3 magnesium stearate (MgST) formulation improved in MMAD 2.2±0.8μm. In presence on 2 NGI, amount deposited increased 4-fold 4.8±0.7% 19.5±3.3%. appeared highly their deposition most stages NGI changed compared absence magnet. If pharmaceutical active ingredient, useful for treating localised disease such as cancer nodules bacterial infectious foci.