Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells.
作者： Ana Carolina Baptista Moreno Martin , Ana Carolina Ferreira Cardoso , Heloisa Sobreiro Selistre-de-Araujo , Márcia Regina Cominetti
DOI: 10.4161/19336918.2014.994917
关键词:
摘要: One of the most important features malignant cells is their capacity to invade adjacent tissues and metastasize distant organs. This process involves creation, by tumor stroma cells, a specific microenvironment, suitable for proliferation, migration invasion cells. The ADAM family proteins has been involved in these processes. work aimed investigate role recombinant disintegrin domain human ADAM9 (rADAM9D) on adhesive mobility properties DU145 prostate rADAM9D was able support cell adhesion, inhibit as well this line through matrigel vitro. Overall demonstrates that induces cellular migratory when compared with different constructs having additional domains, specially those metalloproteinase cysteine-rich domains. Furthermore, we showed mainly t...
sci-hub.se 参考文章(28)
Anne L. Stone, Michaela Kroeger, Qing Xiang Amy Sang, Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review). Journal of Protein Chemistry. ,vol. 18, pp. 447- 465 ,(1999) , 10.1023/A:1020692710029
A.J. Docherty, G. Murphy, P.M. Slocombe, D. Nath, A. Webster, P.E. Stephens, Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility. Journal of Cell Science. ,vol. 113, pp. 2319- 2328 ,(2000) , 10.1242/JCS.113.12.2319
Colette M. Witkowski, Isaac Rabinovitz, Raymond B. Nagle, Kit-Sahn D. Affinito, Anne E. Cress, Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines. Journal of Cancer Research and Clinical Oncology. ,vol. 119, pp. 637- 644 ,(1993) , 10.1007/BF01215981
Abdullah Karadag, Min Zhou, Peter I. Croucher, ADAM-9 (mdc-9/meltrin-γ), a member of the a disintegrin and metalloproteinase family, regulates myeloma cell induced interleukin-6 production in osteoblasts by direct interaction with the αvβ5-integrin Blood. ,vol. 107, pp. 3271- 3278 ,(2006) , 10.1182/BLOOD-2005-09-3830
Paola Zigrino, Julia Steiger, Jay W. Fox, Stefanie Löffek, Alexander Schild, Roswitha Nischt, Cornelia Mauch, Role of ADAM-9 Disintegrin-Cysteine-rich Domains in Human Keratinocyte Migration Journal of Biological Chemistry. ,vol. 282, pp. 30785- 30793 ,(2007) , 10.1074/JBC.M701658200
Sajni Josson, Cynthia S. Anderson, Shian-Ying Sung, Peter A.S. Johnstone, Hiroyuki Kubo, Chia-Ling Hsieh, Rebecca Arnold, Murali Gururajan, Clayton Yates, Leland W.K. Chung, Inhibition of ADAM9 Expression Induces Epithelial Phenotypic Alterations and Sensitizes Human Prostate Cancer Cells to Radiation and Chemotherapy The Prostate. ,vol. 71, pp. 232- 240 ,(2011) , 10.1002/PROS.21237
Carl P. Blobel, ADAMs: key components in EGFR signalling and development Nature Reviews Molecular Cell Biology. ,vol. 6, pp. 32- 43 ,(2005) , 10.1038/NRM1548
Lucie Peduto, ADAM9 as a potential target molecule in cancer. Current Pharmaceutical Design. ,vol. 15, pp. 2282- 2287 ,(2009) , 10.2174/138161209788682415
Soichi Takeda, Tomoko Igarashi, Hidezo Mori, Satohiko Araki, Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. The EMBO Journal. ,vol. 25, pp. 2388- 2396 ,(2006) , 10.1038/SJ.EMBOJ.7601131
Jun Zhang, Ning Chen, Juan Qi, Baosen Zhou, Xueshan Qiu, HDGF and ADAM9 are novel molecular staging biomarkers, prognostic biomarkers and predictive biomarkers for adjuvant chemotherapy in surgically resected stage I non-small cell lung cancer. Journal of Cancer Research and Clinical Oncology. ,vol. 140, pp. 1441- 1449 ,(2014) , 10.1007/S00432-014-1687-2