In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse.

作者: Deborah A. Nicoll-Griffith , Nathalie Chauret , Jean Martin , Annick Gauthier

DOI:

关键词:

摘要: … in a 100 mM phosphate buffer at pH 7.4 (except for coumarin … affect the various P450 catalytic activities. Considering the limited amount of data available on hepatic cytochromes P450 …

参考文章(39)
A. David Rodrigues, Use of in vitro human metabolism studies in drug development: An industrial perspective Biochemical Pharmacology. ,vol. 48, pp. 2147- 2156 ,(1994) , 10.1016/0006-2952(94)00312-2
Masayuki Komori, Atsuko Higami, Yoshio Imai, Susumu Imaoka, Yoshihiko Funae, Purification and Characterization of a Form of P450 from Horse Liver Microsomes The Journal of Biochemistry. ,vol. 114, pp. 445- 448 ,(1993) , 10.1093/OXFORDJOURNALS.JBCHEM.A124195
John O Miners, Kerry J Smith, Richard A Robson, Michael E McManus, Maurice E Veronese, Donald J Birkett, Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations. Biochemical Pharmacology. ,vol. 37, pp. 1137- 1144 ,(1988) , 10.1016/0006-2952(88)90522-9
D. J. Newton, R. W. Wang, A. Y. H. Lu, Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. Drug Metabolism and Disposition. ,vol. 23, pp. 154- 158 ,(1995)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
S N Binkley, S A Wrighton, L A Shipley, J E Sharer, M R Vandenbranden, Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Drug Metabolism and Disposition. ,vol. 23, pp. 1231- 1241 ,(1995)
L C Quattrochi, J O Miners, R H Tukey, M E McManus, H V Gelboin, D J Birkett, M E Veronese, W Tassaneeyakul, Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. Journal of Pharmacology and Experimental Therapeutics. ,vol. 265, pp. 401- 407 ,(1993)
Gustavo Martínez-Zedillo, Carmen Castilho-Alonso, Victor M. Magdaleno, Amador González-Angulo, Cytochrome P-450 and parathon metabolism in the fetal and adult gonads of the horse Life Sciences. ,vol. 25, pp. 327- 331 ,(1979) , 10.1016/0024-3205(79)90262-5
S.A. Wrighton, J.C. Stevens, G.W. Becker, M. Vandenbranden, Isolation and characterization of human liver cytochrome P450 2C19 : correlation between 2C19 and S-mephenytoin 4'-hydroxylation Archives of Biochemistry and Biophysics. ,vol. 306, pp. 240- 245 ,(1993) , 10.1006/ABBI.1993.1506