Neurophysiology of dystonia: The role of inhibition

摘要: Abstract The pathophysiology of dystonia has been best studied in patients with focal hand dystonia. A loss inhibitory function demonstrated at spinal, brainstem and cortical levels. Many circuits seem to be involved. One consequence the inhibition is a failure surround inhibition, this appears directly lead overflow unwanted muscle spasms. There are mild sensory abnormalities deficits sensorimotor integration; these also might explained by inhibition. Increasing may therapeutic. possible hypothesis that there genetic interneurons deficit substrate on which other factors can act produce This article part Special Issue entitled “Advances dystonia”.