作者: HENRY METZGER , MARVIN B. SHAPIRO , JAMES E. MOSIMANN , JAY E. VINTON
DOI: 10.1038/2191166A0
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摘要: IT is sometimes desirable to study the possible relationship of two proteins when sequence data are unavailable. Few methods useful for such an analysis: molecular size, functional criteria, genetic localization, end group analysis, tryptic fingerprints all have serious shortcomings. Immunological criteria may be cross-reactivity found, but frequently one earliest common features lost. A criterion amino-acid composition. Despite considerable changes in protein structure brought about by a limited number changes, overall composition evolutionary related can expected remain quite similar. We wish present simple method assessing and describing compositional relatedness.