Influence of acoustic stress by noise on gastrointestinal motility in dogs

摘要: The effects of acoustic stress (AS) on gastrointestinal motility and their prevention by previous treatment with naloxone, phentolamine, propranolol, muscimol, diazepam were investigated in intact vagotomized fasted dogs fitted chronically implanted strain gauges the antrum at 10 cm from pylorus jejunum 70 140 pylorus. These compared to those produced intracerebroventricular administration ovine corticotropin releasing factor (oCRF). Beginning 40–50 min after occurrence a gastric migrating motor complex (MMC), 1-hr hearing prerecorded intense music through earpieces (<100 dB) delayed next MMC observed 2.8±1.2 hr, while jejunal still present normal frequency. During AS, heart rate plasma cortisol significantly increased 32.7 215%, respectively, 10–15 beginning hearing. AS-induced lengthening cycle as well increase abolished (0.5 mg/kg intramuscular) or muscimol (10 μg/kg intravenous), they naloxone (0.1 phentolamine (0.2 propranolol intravenous). CRF administered intracerebroventricularly (100 ng/kg) also without affecting motility, this effect was not antagonized muscimol. Both AS bilateral thoracic vagotomy. results suggest that selective inhibition induced noise dog is due CNS release which affects, turn, vagal output stomach. suppressive action GABA agonist noise-induced hypomotility may be related blockade release.