Stereochemistry of Seven-Membered Heterocycles: XLI. Stereoselective Synthesis of 3-R-1,5-Dihydro-2,4-benzothiepine 2-Oxides
作者： P. A. Kikilo , B. I. Khairutdinov , R. A. Shaikhutdinov , Yu. G. Shtyrlin , V. V. Klochkov
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摘要: The oxidation of 3-R-1,5-dihydro-2,4-benzothiepines with m-chloroperbenzoic acid occurs in a highly diastereoselective fashion. resulting trans-sulfoxides at -60°C CDCl3 exist as an equilibrium mixture the chair and boat forms substituents equatorial position. fraction conformation increases series R = Ph, Me, t-Bu.
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