Short-term administration of granulocyte-macrophage colony stimulating factor decreases hematopoietic toxicity of cytostatic drugs

摘要: Background. Administration of granulocyte-macrophage colony stimulating factor (GM-CSF) is followed by a rapid increase in the proliferative activity hematopoietic precursors. Within 72 hours after its suspension, however, establishment negative feedback results reduction hyperplastic marrow to values below baseline, suggesting refractoriness progenitors action cell-cycle-specific cytostatic agents. Methods. The hypothesis that short treatment with GM-CSF before chemotherapy could reduce toxicity cytostatics was investigated administering glycosylate (Sandoz, Basel, Switzerland/Schering-Plough, Kenilwortb, NJ) subcutaneously 5.5 pg/kg protein dosage per day from -6-day -4 each course adjuvant (cyclophosphamide, epirubicin, 5-fluorouracil/cyclophosphamide, methotrexate, 5-fluorouracil alternate) patients node-positive breast cancer. Twelve were randomized receive or only at chemotherapy. hematologic picture and dose intensity compared two groups patients. Results. In group receiving only, 22% cycles had be postponed because leukopenia, consequent intensity, whereas group, neutrophil