Effect of two oral contraceptives containing ethinyl estradiol and gestodene or norgestimate on different lipid and lipoprotein parameters

摘要: The effect of a triphasic oral contraceptive containing ethinyl estradiol and gestodene (EE/GSD) on various lipid lipoprotein parameters was compared with that monophasic formulation 35 micrograms 250 norgestimate (EE/NGM). Blood samples were collected from 46 women days 2, 11, 21 the preceding control cycle third, sixth, twelfth treatment cycles. There no significant difference between formulations regard to influence any measured parameter. As controls, increase observed in plasma levels total triglycerides (24-78%), phospholipids (7-20%), very low density (VLDL) (61-76%), VLDL-phospholipids (14-60%), (LDL) (8-35%), LDL-phospholipids (28-30%), high (HDL) cholesterol (8-16%), HDL 3-cholesterol (11-20%), HDL-triglycerides (17-66%), HDL-phospholipids, 3-phospholipids (7-11%), apolipoprotein (apo) A-I (5-20%) apo A-II (10-40%) during both formulations. In contrast, LDL-cholesterol significantly decreased. These changes metabolism appear reflect predominance estrogen component. results indicate dose contraceptives different progestins amounts EE do not exert deleterious metabolism, as HDL-cholesterol are known risk factors cardiovascular disease. contrast endogenous hypertriglyceridemia, an EE-induced rise triglyceride does if LDL is increased.