An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction
作者： Toshiaki Sasada , Fuminori Kobayashi , Norio Sakai , Takeo Konakahara
DOI: 10.1021/OL900382J
关键词:
摘要: We have developed a ZnCl2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4, 5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono-and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.
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