The serum proteins in health and disease

摘要: Abstract The results of electrophoretic determinations the serum proteins in a group 100 normal subjects and with wide variety disease are summarized. observations indicate that total quantity concentration various globulin components subject remain fairly constant within relatively narrow range. Determinations showing significant deviation from values have not, general, been consistent continued good health. At same time it should be stressed patterns may observed proportion most diseases which included this study. Hyperglobulinemia hypergammaglobulinemia states including rheumatoid arthritis other "collagen diseases," chronic liver disease, ulcerative colitis, sarcoidosis, certain infective states, types thrombocytopenic non-thrombocytopenic purpura, cryoglobulinemias macroglobulinemias, lymphomas, multiple myeloma, primary amyloid some obscure illnesses definite diagnosis can not made even after autopsy examination. An increase gamma over its whole breadth, such as commonly occurs arthritis, systemic lupus erythematosus related is distinctive appears to little diagnostic value than reflect disturbance antibody-producing mechanism. appearance abnormal protein constituents, however, occurring bands usually located somewhere region beta or components, distinct diagnosis. Such were myeloma. Not infrequently similar shown urine, present instance was consistently demonstrated myeloma whenever there an associated proteinuria. demonstration by analysis since they smaller illnesses, accurate could either clinically postmortem While simple matter determine whether cryoglobulins cases, presence macroglobulins verified only ultra-centrifugal Examination patients clinical picture nephrotic syndrome helpful differentiating nephrosis due glomerulonephritis renal involvement, when characteristic changes lacking. Patients resulting showed greatly increased alpha 2 fraction reduced globulin, contrast apha manifestations. In agammaglobulinemia hypogammaglobulinemia causes, reliable method demonstrating deficiency.