An eco-friendly three-component regio- and stereoselective synthesis of highly functionalized dihydroindeno[1,2-b]pyrroles under grinding
作者： Sivasubramanian Muthusaravanan , Chinnathambi Sasikumar , Balasubramanian Devi Bala , Subbu Perumal
DOI: 10.1039/C3GC42150C
关键词:
摘要: Facile three-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones with anilines and ninhydrin in an equimolar ratio upon grinding the presence acetic acid (0.1 ml per mmol reactants) afforded highly functionalized dihydroindeno[1,2-b]pyrroles regio- stereoselectively good yields. This protocol has advantages such as solvent-free under grinding, ambient temperature, short reaction times, simple work-up avoiding chromatographic purification excellent
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