α-Gal Epitopes on Viral Glycoproteins
作者： Russell P. Rother , Uri Galili
DOI: 10.1007/978-1-4615-4771-6_7
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摘要: The α-gal epitope (Galα1,3Galβl,4GlcNAc-R) is a terminal glycosidic structure that expressed on the surface of cells from most mammalian species other than humans, apes and Old World monkeys (Galili et al., 1988a; Galili 1987). α-galactosyl unit this added to nascent glycolipids glycoproteins in Golgi apparatus by α1,3galactosyltransferase (α1,3GT). In primates lacking epitope, α1,3GT gene not transcribed, nonsense mutations are present within coding region some Swanson, 1991; Larsen 1990a; Joziasse 1989). presence functional New suggests was inactivated ancestral after their divergence 1988a). A detailed comparison pseudogene sequences further these two groups diverged each Andrews, 1995; 1991).
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