Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities.

Chris Jones, Suzanne J. Baker, Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma Nature Reviews Cancer. ,vol. 14, pp. 651- 661 ,(2014) , 10.1038/NRC3811

Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter Lewis, Eric Bouffet, Ute Bartels, Jennifer Zuccaro, Sameer Agnihotri, Scott Ryall, Mark Barszczyk, Yevgen Chornenkyy, Mathieu Bourgey, Guillaume Bourque, Alexandre Montpetit, Francisco Cordero, Pedro Castelo-Branco, Joshua Mangerel, Uri Tabori, King Ching Ho, Annie Huang, Kathryn R Taylor, Alan Mackay, Anne E Bendel, Javad Nazarian, Jason R Fangusaro, Matthias A Karajannis, David Zagzag, Nicholas K Foreman, Andrew Donson, Julia V Hegert, Amy Smith, Jennifer Chan, Lucy Lafay-Cousin, Sandra Dunn, Juliette Hukin, Chris Dunham, Katrin Scheinemann, Jean Michaud, Shayna Zelcer, David Ramsay, Jason Cain, Cameron Brennan, Mark M Souweidane, Chris Jones, C David Allis, Michael Brudno, Oren Becher, Cynthia Hawkins, Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Nature Genetics. ,vol. 46, pp. 451- 456 ,(2014) , 10.1038/NG.2936

Amar Gajjar, Stefan M. Pfister, Michael D. Taylor, Richard J. Gilbertson, Molecular Insights into Pediatric Brain Tumors Have the Potential to Transform Therapy Clinical Cancer Research. ,vol. 20, pp. 5630- 5640 ,(2014) , 10.1158/1078-0432.CCR-14-0833

Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola, Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood Journal of Neuro-oncology. ,vol. 118, pp. 305- 312 ,(2014) , 10.1007/S11060-014-1428-Z

Dong-Anh Khuong-Quang, Pawel Buczkowicz, Patricia Rakopoulos, Xiao-Yang Liu, Adam M. Fontebasso, Eric Bouffet, Ute Bartels, Steffen Albrecht, Jeremy Schwartzentruber, Louis Letourneau, Mathieu Bourgey, Guillaume Bourque, Alexandre Montpetit, Genevieve Bourret, Pierre Lepage, Adam Fleming, Peter Lichter, Marcel Kool, Andreas von Deimling, Dominik Sturm, Andrey Korshunov, Damien Faury, David T. Jones, Jacek Majewski, Stefan M. Pfister, Nada Jabado, Cynthia Hawkins, K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathologica. ,vol. 124, pp. 439- 447 ,(2012) , 10.1007/S00401-012-0998-0

Gang Wu, Alexander K Diaz, Barbara S Paugh, Sherri L Rankin, Bensheng Ju, Yongjin Li, Xiaoyan Zhu, Chunxu Qu, Xiang Chen, Junyuan Zhang, John Easton, Michael Edmonson, Xiaotu Ma, Charles Lu, Panduka Nagahawatte, Erin Hedlund, Michael Rusch, Stanley Pounds, Tong Lin, Arzu Onar-Thomas, Robert Huether, Richard Kriwacki, Matthew Parker, Pankaj Gupta, Jared Becksfort, Lei Wei, Heather L Mulder, Kristy Boggs, Bhavin Vadodaria, Donald Yergeau, Jake C Russell, Kerri Ochoa, Robert S Fulton, Lucinda L Fulton, Chris Jones, Frederick A Boop, Alberto Broniscer, Cynthia Wetmore, Amar Gajjar, Li Ding, Elaine R Mardis, Richard K Wilson, Michael R Taylor, James R Downing, David W Ellison, Jinghui Zhang, Suzanne J Baker, St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project, The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma Nature Genetics. ,vol. 46, pp. 444- 450 ,(2014) , 10.1038/NG.2938

A. M. Cappellano, A. A. Senerchia, F. Adolfo, P. M. Paiva, R. Pinho, A. Covic, S. Cavalheiro, N. Saba, Successful everolimus therapy for SEGA in pediatric patients with tuberous sclerosis complex. Childs Nervous System. ,vol. 29, pp. 2301- 2305 ,(2013) , 10.1007/S00381-013-2170-0

Sabine Wagner, Monika Warmuth-Metz, Angela Emser, Astrid-K. Gnekow, Ronald Sträter, Stefan Rutkowski, Norbert Jorch, Hans-J. Schmid, Frank Berthold, Norbert Graf, Rolf-D. Kortmann, Thorsten Pietsch, Norbert Sörensen, Ove Peters, Johannes E.A. Wolff, Treatment options in childhood pontine gliomas. Journal of Neuro-oncology. ,vol. 79, pp. 281- 287 ,(2006) , 10.1007/S11060-006-9133-1

Kathryn R Taylor, Alan Mackay, Nathalène Truffaux, Yaron S Butterfield, Olena Morozova, Cathy Philippe, David Castel, Catherine S Grasso, Maria Vinci, Diana Carvalho, Angel M Carcaboso, Carmen De Torres, Ofelia Cruz, Jaume Mora, Natacha Entz-Werle, Wendy J Ingram, Michelle Monje, Darren Hargrave, Alex N Bullock, Stéphanie Puget, Stephen Yip, Chris Jones, Jacques Grill, None, Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma Nature Genetics. ,vol. 46, pp. 457- 461 ,(2014) , 10.1038/NG.2925

Marc C. Chamberlain, Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series. Journal of Neuro-oncology. ,vol. 114, pp. 237- 240 ,(2013) , 10.1007/S11060-013-1176-5