Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish

摘要: Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem progenitor or reprogramming differentiated into regeneration-competent precursors. Proliferation among that will functionally restore injured is a fundamental biological process underlying regeneration. Midkine-a cytokine growth factor, whose expression strongly induced injury in variety of across range vertebrate classes. Using zebrafish loss function mutant, we evaluated regeneration caudal fin, extraocular muscle retinal neurons investigate during epimorphic In wildtype zebrafish, these induces robust proliferation rapid mutants, initial each significantly diminished absent. Regeneration fin delayed; retina nearly completely These data demonstrate universally required signaling pathways convert tissue burst cell proliferation. Further, highlight differences molecular mechanisms regulate zebrafish.