ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions

摘要: The extent of drug metabolism or transport-based pharmacokinetic drug–drug interactions is highly variable between individuals. CYP enzymes such as CYP2B6, CYP2C9, CYP2C19, and CYP2D6 efflux uptake transporters ABCB1 OAT1B1 display genetic polymorphisms (presence variants in at least 1% a population) that may result altered transport capacities, respectively. These explain the interindividual magnitude interaction to significant by determining either substrate susceptibility for potential an inducer inhibitor. Knowledge activity enzyme responsible affected inhibitor can offer vital information when assessing interactions. Drug are increasingly recognized supplement this information. Nowadays, metabolic statuses easily accessible genotyping important prerequisite fully judge