Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review.
关键词:
摘要: In addition to genetic factors, environmental triggers, including viruses and other pathogens, are thought play a major role in the development of autoimmune disease. Recent findings have shown that viral-induced autoimmunity is likely be genetically determined. large-scale analyses, an association interferon induced with helicase C domain 1 (IFIH1) gene variants encoding viral RNA-sensing susceptibility several diseases was found. To date, precise IFIH1 pathogenic mechanisms has yet fully elucidated. However, recent reports suggest may etiology type diabetes. Rare alleles been protective against diabetes, their carriage correlates lower production this its functional disruption. contrast, upregulation expression by associated more severe disease, could exacerbate process susceptible individuals.
liebertonline.com参考文章(116)
M. Eric Gershwin, Lorenzo Rossaro, Massimo Zuin, Ana Lleo, Mauro Podda, Carlo Selmi, Interferon alpha and its contribution to autoimmunity. Current opinion in investigational drugs. ,vol. 7, pp. 451- 456 ,(2006)
Stephen D. Miller, Yael Katz-Levy, Katherine L. Neville, Carol L. Vanderlugt, Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system Advances in Virus Research. ,vol. 56, pp. 199- 217 ,(2001) , 10.1016/S0065-3527(01)56008-X
Paul, P. Tak, IFN-beta in rheumatoid arthritis. Frontiers in Bioscience. ,vol. 9, pp. 3242- 3247 ,(2004) , 10.2741/1475
Carola G. Vinuesa, Matthew C. Cook, Genetic analysis of systemic autoimmunity. Novartis Foundation symposium. ,vol. 281, pp. 103- 128 ,(2007) , 10.1002/9780470062128.CH10
A Boyhan, C.M. Casimir, J.K. French, C.G. Teahan, A.W. Segal, Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. Journal of Biological Chemistry. ,vol. 267, pp. 2928- 2933 ,(1992) , 10.1016/S0021-9258(19)50675-5
Julie K. Olson, J. Ludovic Croxford, Miriam. A. Calenoff, Mauro C. Dal Canto, Stephen D. Miller, A virus-induced molecular mimicry model of multiple sclerosis Journal of Clinical Investigation. ,vol. 108, pp. 311- 318 ,(2001) , 10.1172/JCI200113032
Ken Takahashi, Taro Kawai, Himanshu Kumar, Shintaro Sato, Shin Yonehara, Shizuo Akira, Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. Journal of Immunology. ,vol. 176, pp. 4520- 4524 ,(2006) , 10.4049/JIMMUNOL.176.8.4520
S. Myong, S. Cui, P. V. Cornish, A. Kirchhofer, M. U. Gack, J. U. Jung, K.-P. Hopfner, T. Ha, Cytosolic Viral Sensor RIG-I Is a 5′-Triphosphate-Dependent Translocase on Double-Stranded RNA Science. ,vol. 323, pp. 1070- 1074 ,(2009) , 10.1126/SCIENCE.1168352
Laura Papon, Alexandra Oteiza, Tadaatsu Imaizumi, Hiroki Kato, Emiliana Brocchi, T. Glen Lawson, Shizuo Akira, Nadir Mechti, The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology. ,vol. 393, pp. 311- 318 ,(2009) , 10.1016/J.VIROL.2009.08.009
Darja Bamming, Curt M. Horvath, Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2 Journal of Biological Chemistry. ,vol. 284, pp. 9700- 9712 ,(2009) , 10.1074/JBC.M807365200