The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines.
作者： Takeo Saneyoshi , Yasunori Hayashi
DOI: 10.1002/CM.21037
关键词:
摘要: Most excitatory synapses reside on small protrusions located the dendritic shaft of neurons called spines. Neuronal activity regulates number and structure spines in both developing mature brains. Such morphological changes are mediated by modification actin cytoskeleton, major structural component Because size is tightly correlated with strength synaptic transmission, activity-dependent remodeling a spine plays an important role modulation transmission. The regulation morphogenesis utilizes multiple intracellular signaling pathways that alter dynamics remodeling. Here, we will review recent studies examining underlying at postsynaptic neurons.
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