Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform

摘要: Abstract A thermosensitive/magnetic poly(organophosphazene) hydrogel (a magnetic hydrogel) was designed and synthesized for long-term resonance (MR) imaging. To turn a thermosensitive (an original into MR contrast platform, cobalt ferrite (CoFe2O4) nanoparticles, which have hydrophobic surfaces, were bound to the via interactions between surfaces of nanoparticles L-isoleucine ethyl esters polymer. The showed extremely low cytotoxicity adequate properties use in imaging, addition possessing same hydrogel, such as viscosity, thermosensitivity, biodegradability, biocompatibility, reversible sol-to-gel phase transition near body temperature, injectability. injected rat brain using stereotactic surgery. After injection, applicable potentiality platform successfully estimated over 4–5 weeks. Consequently, it shown that has potential be applied theranostic system. Furthermore, is expected this can useful clinical field incurable diseases due either surgical difficulties or lethality, with tumors, when combined therapeutic drugs theragnosis further studies.