Drug interactions between hormonal contraceptives and antiretrovirals.

摘要: OBJECTIVE: To summarize published evidence on drug interactions between hormonal contraceptives and antiretrovirals. DESIGN: Systematic review of the literature. METHODS: We searched PUBMED POPLINE EMBASE for peer-reviewed publications studies (in any language) from inception through September 21 2015. included women using antiretrovirals concurrently. Outcomes interest were effectiveness either therapy toxicity pharmacokinetics. used standard abstraction forms to assess strengths weaknesses. RESULTS: Fifty reports 46 included. Most whether or prevention have limited with contraceptive methods exception efavirenz. While DMPA is not affected data implants combined oral pills suggests that efavirenz-containing combination antiretroviral may compromise these methods. However remain very effective despite such interactions. Antiretroviral plasma concentrations are generally by contraceptives. CONCLUSION: Women taking treatment should be denied access full range options but counseled expected rates unplanned pregnancy associated all in order make their own informed choices.