P 024 - Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson’s disease patients treated with DBS STN

摘要: Abstract Disorders of gait seriously affect the functional state and quality life patients with Parkinson’s disease (PD). Impaired brain function underlies disorders movement control in PD, however imaging magnetic resonance (fMRI) is not feasible during gait. Near-Infrared Spectroscopy (NIRS) a portable method for measuring activity. It uses low-energy optical radiation to detect local changes (de)oxyhemoglobin concentration cerebral cortex, like fMRI. We included 8 advanced PD chronically treated DBS STN. Brain activity was recorded NIRSport. Gait examined 10 cycles, which active resting phases alternated. Changes oxyhemoglobin were calculated from native NIRS signal using modified transformation Lambert-Beer Law. The signals filtered 0.015–0.3 Hz band least-squares algorithm fitted HRF each cycle separately, median finally calculated. motor cortex significantly higher OFF compared ON (p = 0.02). In contrast, other regions no differences found. A shown may reflect impairment PD. general terms, present study demonstrates potential utility detecting