Surface NK receptors and their ligands on tumor cells

摘要: The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation why NK cells can kill target that have lost or underexpress I molecules but spare normal cells. However, the molecular basis NK-mediated recognition tumor cell killing revealed higher degree complexity. Thus, under pathological conditions, may express insufficient amounts triggering not ligands for such receptors. Here we briefly illustrate main their cellular delineate major receptor/ligands interactions leading to activation lysis.