Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila
作者： Shu Kondo , Toshiharu Ichinose , Hiromu Tanimoto , Shun Hiramatsu , Mai Kanno
DOI: 10.1038/S41598-021-82813-0
关键词:
摘要: Dysregulated motivation to consume psychoactive substances leads addictive behaviors that often result in serious health consequences. Understanding the neuronal mechanisms drive drug consumption is crucial for developing new therapeutic strategies. The fruit fly Drosophila melanogaster offers a unique opportunity approach this problem with battery of sophisticated neurogenetic tools available, but how they these drugs remains largely unknown. Here, we examined self-administration behavior and underlying mechanisms. We measured preference flies five different using two-choice feeding assay monitored its long-term changes. found show acute ethanol methamphetamine, not cocaine, caffeine or morphine. Repeated intake ethanol, increased over time. Preference methamphetamine escalation required dopamine receptor Dop1R1 mushroom body. protein level after repeated which correlates acquired preference. Genetic overexpression enhanced These results reveal striking diversity response individual role signaling plastic changes controlling voluntary drugs.
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