GLOMERULAR HYPERFILTRATION AFTER PROTEIN INGESTION, DURING GLUCAGON INFUSION, AND IN INSULIN-DEPENDENT DIABETES IS INDUCED BY A LIVER HORMONE: DEFICIENT PRODUCTION OF THIS HORMONE IN HEPATIC FAILURE CAUSES HEPATORENAL SYNDROME
作者： Anders Alvestrand , Jonas Bergström
DOI: 10.1016/S0140-6736(84)92115-9
关键词:
摘要: Glomerular hyperfiltration induced by various stimuli (protein ingestion, amino-acid infusion, glucagon diabetes mellitus) is postulated to be associated with increased secretion the liver of a hormone that increases glomerular filtration rate. In severe failure deficient this presumed cause or contribute development hepatorenal syndrome. There evidence hepatic uptake aminoacids factor triggering hormone. The hypothesis, which based on earlier published studies in laboratory animals and man, accords well clinical observations. This hypothesis may explain how glomeruli respond metabolic raises possibility therapeutic intervention chronic renal failure.
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